Filaria in the muscles and labium of Culex
When the blood of an infested individual is sucked up and reaches the stomach of such a mosquito, the larvæ, by very active movements, escape from their sheaths and within a very few hours actively migrate to the body cavity of their new host and settle down primarily in the thoracic muscles. There in the course of sixteen to twenty days they undergo a metamorphosis of which the more conspicuous features are the formation of a mouth, an alimentary canal and a trilobed tail. At the same time there is an enormous increase in size, the larvæ which measured .3 mm. in the blood becoming 1.5 mm. in length. This developmental period may be somewhat shortened in some cases and on the other hand may be considerably extended. The controlling factor seems to be the one of temperature. The transformed larvæ then reenter the body cavity and finally the majority of them reach the interior of the labium. A few enter the legs and antennæ, and the abdomen, but these are wanderers which, it is possible, may likewise ultimately reach the labium, where they await the opportunity to enter their human host.
Trypanosoma brucei
By trypanosomiasis is meant a condition of animal parasitism, common to man and the lower animals, in which trypanosomes, peculiar flagellate protozoa, infest the blood. Depending upon the species, they may be harmless, producing no appreciable ill-effect, or pathogenic, giving rise to conditions of disease. A number of these are known to be transferred by insects. The trypanosomes are elongated, usually pointed, flagellated protozoa in which the single flagellum, bent under the body, forms the outer limit of a delicate undulating membrane. It arises near one end of the organism from a minute centrosome-like body which is known as the blepheroplast, and at the opposite end extends for a greater or less distance as a free flagellum. Enclosing, or close beside the blepheroplast is the small kinetonucleus. The principal nucleus, round or oval in form, is situated near the center of the body. Asexual reproductions occurs in this stage, by longitudinal fission, the nucleus and the blepheroplast dividing independently of one another. From the blepheroplast of one of the daughter cells a new flagellum is formed.
Ornithodoros moubata
(a) Anterior part of venter (b) second stage nymph (c) capitulum (d) dorsal aspect of female (e) ventral aspect of female (f) ventral aspect of nymph (g) capitulum of nymph Ornithodoros moubata, the carrier of African relapsing fever, or "tick-fever," is widely distributed in tropical Africa, and occurs in great numbers in the huts of natives, in the dust, cracks and crevices of the dirt floors, or the walls. It feeds voraciously on man as well as upon birds and mammals. Like others of the Argasidæ, it resembles the bed-bug in its habit of feeding primarily at night. Dutton and Todd observed that the larval stage is undergone in the egg and that the first free stage is that of the octopod nymph.
Spirochæta gallinarum. After Hindle.
Spirochætosis of Fowls—One of the best known of the spirochætes transmitted by arthropods is Spirochæta gallinarum, the cause of a very fatal disease of domestic fowls in widely separated regions of the world. According to Nuttall, it occurs in Southeastern Europe, Asia, Africa, South America and Australia. In 1903, Marchoux and Salimbeni, working in Brazil, made the first detailed study of the disease, and showed that the causative organism is transmitted from fowl to fowl by the tick Argas persicus. They found that the ticks remained infective for at least five months. Specimens which had fed upon diseased birds in Brazil were sent to Nuttall and he promptly confirmed the experiments.